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Fluralaner 864731-61-3 Certification Of Analysis

Number of visits: Date:2018-04-08 14:40:08
Fluralaner 864731-61-3  manufacturer 

Certification Of Analysis

Test  item Unit Test  Specification Result
Purity % ≥96% 99%
Appearance   White powder Confirms
Pathway: Anti-infection
Solubility: DMSO: ≥ 221 mg/mL
conclusion  Product confirms to the specifications

BIOLOGICAL ACTIVITY: Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels. In Vitro: Fluralaner potently inhibits flea reproduction capacity in vitro. Oviposition ceases completely at concentrations as low as 25.0 ng/mL. While no ovicidal effect is observed, fluralaner exerts a larvicidal effect at exceptionally low concentrations (6.25 ng/mL)[1] . In Vivo: In the simulated flea-infested home environment, flea-control efficacy on fluralaner-treated dogs is >99% at every time point measured for 12 weeks. No adverse events are observed in fluralaner-treated dogs. Fluralaner completely controls egg laying, larval development and flea reproduction even at sub-insecticidal concentrations. Oral treatment of dogs with fluralaner is highly effective for eliminating fleas in a simulated flea-infested home environment[1] . After single oral administration of Bravecto chewable tablets, mite numbers in skin scrapings are reduced by 99.8% on Day 28 and by 100% on Days 56 and 84. A marked decrease is observed in the occurrence of erythematous patches, crusts, casts and scales in the dogs treated with Bravectco[2] . PROTOCOL (Extracted from published papers and Only for reference) Animal Administration: [2]Dogs: Thirty-two (16 male and 16 female) healthy 8-week old Beagle dogs weighing 2.0 - 3.6 kg at first administration are included in the study. Fluralaner is administered on three occasions at 8-week intervals at doses of up to 56, 168, and 280 mg fluralaner/kg body weight, equivalent to 1, 3, and 5 times the highest recommended treatment dose of fluralaner; sham dosed dogs served as controls[2] .
eferences: [1]. Williams H, et al. Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in asimulated home environment. Parasit Vectors. 2014 Jun 19;7:275. [2]. Walther FM, et al. Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1(-/-) Collies after oral administration. Parasit Vectors. 2014 Mar 6;7:86.
Caution: Product has not been fully validated for medical applications. For research use only.

TypeInfo: Product Information


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